Cobal

Indications

Cobal is indicated in diabetic neuropathy, alcoholic neuropathy, trigeminal neuralgia, post-herpetic neuralgia, low back pain, sciatica, multiple neuritis, sensory disorders such as: cramps, paresthesia and numbness.

Pharmacological properties

Cobal contains mecobalamin, an antineuritic that improves disturbances in nucleic acid and protein metabolism in nervous tissue. Mecobalamin is vitamin B12 of the coenzyme type, existing in the blood and cerebrospinal fluid.

It is the only homologous compound of vitamin B12 that participates in transmethylation. It facilitates the transfer methylation of RNAS in nerve cells, which play an important role in the synthesis of methionine in glial cells to a greater degree than cobamanide (DBCC).

Mecobalamin increases uridine intake when vitamin B12 and folic acid are deficient and helps restore normal RNAS levels in nerve cells. It also elevates the incorporation of lucina within the crushed nerves. Mecobalamin facilitates the synthesis of nucleic acids and proteins in nerve cells.

– Repairs nervous tissues in experimental nerve injury models.

Mecobalamin inhibits nerve cell degeneration into rat and rabbit induced nerve disorders by experimental acrylamine, adriamycin, or vincristine poisoning. A similar effect has been confirmed by findings obtained with the method of carducing nervous tissue in rats with a broken sciatic nerve. Mecobalamin has been shown to promote the division of Schwann cells and the recovery of atrophied soleus muscle innervated by the sciatic nerve. Mecobalamin has been compared to steroids, in terms of its effects on the process of nerve regeneration, in models of experimental facial paralysis.

Mecobalamin is as effective as steroids in recovering from paralysis.

Improves sensory and motor disturbances

Mecobalamin induces a markedly better response from motor disturbances, such as gait disturbances, diastasis, and abnormal knee reflexes, as well as sensory disturbances, such as numbness and paresthesia.

Drug interactions

  • Ascorbic acid supplements: can decrease the absorption of vitamins B12; This fact should be taken into account if large doses of ascorbic acid are administered within one hour of oral vitamin B12 administration.
  • Absorption of vitamin B12 at the gastrointestinal tract level may be decreased by neomycin, colchicine, antiulcer antihistamines H-2, aminosalicylic acid, omeprazole, anticonvulsants, metformin, cobalt radiation, excessive alcohol intake.
  • Parenteral chloramphenicol: can attenuate the effect of vitamin B12.
  • Oral contraceptives: their use can reduce serum concentrations of vitamin B12.
  • Folic Acid: High doses of folic acid can reduce blood vitamin B12 concentrations and, if administered in case of vitamin B12 deficiency, may mask the hematological effects caused by this deficiency, but exacerbate its neurological consequences.

Posology

 

Adults: 1 tablet of 500 mcg 3 times a day orally. The dose should be adjusted according to the age of the patient and the severity of symptoms.

Cautions

Prolonged use of large doses of mecobalamin is not recommended in patients whose occupation requires the handling of mercury or its compounds.

Side effects

Loss of appetite, nausea, gastrointestinal disorders.

Composition

Each coated tablet contains:

Mecobalamin     500 mcg

C.S. excipients


Administration route

Oral


Presentation

Box containing two blisters with 10 coated tablets each

Box containing five blisters with 10 coated tablets each.