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Tobracin contains Tobramycin, one of several components of an aminoglycoside complex (nebramycin) made by Streptomyces Tenebrarius. Tobramycin is active against sensitive strains of the following microorganisms: Staphylococci, such as: S.aureus and S. epidermidis (Coagulase positive and Coagulase negative), including penicillin resistant strains. Streptococci, including some from the A-beta hemolytic group, some non-hemolytic Streptococcus, and some Streptococcus pneumoniae. Pseudomona aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerógenes, Proteus mirabilis, Morganella morganii, most strains of Proteus vulgaris, Haemophilus influenzae and H. aegyptius, Moraxella lacunata, Anicetobacter calcoaceticus and some strains of. Bacterial susceptibility studies indicate that many microorganisms resistant to gentamicin retain sensitivity to tobramycin. A significant tobramycin-resistant bacterial population has not yet emerged; however, bacterial resistance can develop with prolonged use.
Indications and uses
Tobracin sterile ophthalmic solution is a topical antibiotic indicated for the treatment of external infections of the eye caused by susceptible bacteria. Proper monitoring of the response to topical antibiotic therapy should always accompany the use of Tobracin ophthalmic. Clinical studies have shown that the use of tobramycin in children is safe and effective.
Topical application of Tobracin is not known to cause drug interactions and can be administered concomitantly with eye lubricants, steroids and antiglaucomatous. Total serum concentrations should be monitored if tobramycin is administered topically in combination with systemic aminoglycoside antibiotics. Tobramycin can cause antagonism to develop with any bacteriostatic antibiotic, if used together. Topical anesthetics can increase the absorption of topical drugs and favor the appearance of adverse effects.
Each ml contains:
Excipients and purified water c.s.p. 1ml
Store at 15 and 25 degrees Celsius, protect from freezing.
Box containing a dropper bottle with 5ml of solution.
Tobracin sterile ophthalmic solution is contraindicated in patients who have demonstrated hypersensitivity to any of its components. Some patients may develop sensitivity to topical aminoglycosides. If a reaction or sensitivity to tobramycin is observed, applications should be discontinued.
As with other antibiotic preparations, prolonged use can lead to overgrowth of non-susceptible organisms, including fungi. In case of super infection, the corresponding therapy should be started.
Use during pregnancy and lactation
Tobracin sterile ophthalmic solution should not be used during pregnancy, unless essential. Due to the potential for adverse reactions in infants, the decision will have to be made whether to discontinue breast-feeding or to use the product, depending on its importance to the mother.
In less than 3 out of 100 patients: localized ocular toxicity and hypersensitivity manifested by: itching and inflammation of the eyelids and conjunctival erythema. Similar reactions can occur with the topical use of other aminoglycoside antibiotics.
Posology and method of use
In mild to moderate cases, instill one or two drops into the affected eye or eyes every 4 hours. In severe infections, instill two drops into the affected eye or eyes every hour until improvement is observed. From that moment, the treatment must be reduced before its suspension.
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