ALERPIC is the combination of an antihistamine (pheniramine maleate) and a decongestant (nafazoline hydrochloride).

Indications and uses

Alerpic is indicated in cases of eye irritation and co-management. Allergic or inflammatory eye reactions, conjunctival irritations and hyperemias of diverse origin, such as those caused by dust, smog, smoke, swimming, contact lenses, sun rays, among others.

Drug Interactions

First-generation antihistamines such as pheniramine can increase the CNS depressant effects of various other substances (for example, monoamine oxidase inhibitors, tricyclic antidepressants, alcohol, antiparkinsonians, barbiturates, tranquilizers, and narcotics). Pheniramine can also inhibit the action of anticoagulants and interact with progesterone, reserpine, and thiazide diuretics. Oral contraceptives can decrease the effectiveness of antihistamines. Concomitant use with Naproline or tricyclic antidepressants and Nafazolin may potentiate the pressor effect of Nafazolin. Patients treated with MAO inhibitors may experience severe hypertensive crisis if they receive a sympathomimetic agent.


Each ml contains:

Nafazoline Hydrochloride    0.25mg

Pheniramine Maleate    3mg

C.S.P. Excipients and purified water     1ml




Storage recommendations

Store at 15 and 25 °C, protect from freezing.


Box containing a dropper bottle with 15ml of solution.


Alerpic is contraindicated in cases of hypersensitivity to the components of the formula. If the patient is undergoing medical treatment or suffers from any chronic illness, he should consult his doctor before using Alerpic.

Cautions and Warnings

  • Patients who are receiving MAO inhibitors may experience a severe hypersensitivity crisis if they are administered a sympathomimetic drug such as Nafazolin Hydrochloride.
  • Alerpic should be used with caution in patients with a history of severe cardiovascular disease, including cardiac arrhythmia, diabetic patients, especially those prone to diabetic ketoacidosis.
  • Do not use in the presence of angle-closure glaucoma or in patients with a predisposition to suffer it.
  • Accidental ingestion by infants and children can lead to CNS depression that can lead to coma and a marked decrease in body temperature.
  • Administration with simultaneous use of hydrophilic (soft) contact lenses is not recommended.
  • Do not administer to children under 7 years of age.

Information for patients: To prevent contamination of the Alerpic solution, do not touch the eyelids or the areas adjacent to the eyelids with the tip of the dropper.

Side Effects


The following adverse reactions may occur: pupil dilation, increased intraocular pressure, and systemic effects due to absorption of the drug (eg, hypertension, cardiac abnormalities, hyperglycemia). Drowsiness may occur in some of the patients.

Posology and method of use


Instill 1 to 2 drops of Alerpic into each affected eye, every 3-4 hours or less frequently, as needed to relieve acute symptoms. Do not apply for more than 10 consecutive days.